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Male vitamin D status and male factor infertility.

Publication ,  Journal Article
Banks, N; Sun, F; Krawetz, SA; Coward, RM; Masson, P; Smith, JF; Trussell, JC; Santoro, N; Zhang, H; Steiner, AZ
Published in: Fertility and sterility
October 2021

To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility.Secondary analysis of a randomized, controlled trial.Nine fertility centers in the United States.Men (n = 154) with sperm concentration between 5 and 15 million/mL, motility ≤40%, or normal morphology ≤4% were eligible. Female partners were ovulatory, ≤40 years old, and had documented tubal patency.Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels. They were randomly assigned to receive a vitamin formulation including vitamin D 2,000 IU daily or placebo for up to 6 months. Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6.Primary: sperm concentration, motility, morphology, and DNA fragmentation at baseline. Secondary: cumulative pregnancy, miscarriage, and live birth rates.Semen parameters and sperm DNA fragmentation were not statistically significantly different between men with vitamin D deficiency and men with 25(OH)D levels ≥20 ng/mL. In addition, clinical pregnancy and live birth rates were similar. Male 25(OH)D level <20 ng/mL was associated with a higher rate of pregnancy loss (adjusted odds ratio 9.0; 95% confidence interval 1.3 to 61.3).Vitamin D deficiency in the male partner did not significantly impact semen parameters or treatment outcomes. Further study is warranted to better characterize the rate of miscarriage in couples with male vitamin D deficiency.

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Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

October 2021

Volume

116

Issue

4

Start / End Page

973 / 979

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Treatment Outcome
  • Time Factors
  • Semen Analysis
  • Semen
  • Risk Factors
  • Prospective Studies
  • Pregnancy Rate
 

Citation

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Banks, N., Sun, F., Krawetz, S. A., Coward, R. M., Masson, P., Smith, J. F., … Steiner, A. Z. (2021). Male vitamin D status and male factor infertility. Fertility and Sterility, 116(4), 973–979. https://doi.org/10.1016/j.fertnstert.2021.06.035
Banks, Nicole, Fangbai Sun, Stephen A. Krawetz, R Matthew Coward, Puneet Masson, James F. Smith, J. C. Trussell, Nanette Santoro, Heping Zhang, and Anne Z. Steiner. “Male vitamin D status and male factor infertility.Fertility and Sterility 116, no. 4 (October 2021): 973–79. https://doi.org/10.1016/j.fertnstert.2021.06.035.
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, et al. Male vitamin D status and male factor infertility. Fertility and sterility. 2021 Oct;116(4):973–9.
Banks, Nicole, et al. “Male vitamin D status and male factor infertility.Fertility and Sterility, vol. 116, no. 4, Oct. 2021, pp. 973–79. Epmc, doi:10.1016/j.fertnstert.2021.06.035.
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertility and sterility. 2021 Oct;116(4):973–979.
Journal cover image

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

October 2021

Volume

116

Issue

4

Start / End Page

973 / 979

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Treatment Outcome
  • Time Factors
  • Semen Analysis
  • Semen
  • Risk Factors
  • Prospective Studies
  • Pregnancy Rate