Contribution of 3CD Region to the Virulence of Enterovirus 71.

Journal Article (Journal Article)

Enterovirus 71 is a neuroinvasive virus that is associated with severe neurological complications. We had earlier suggested that the replication capacity of a severe strain was higher than that of a mild strain. The recombinant 3CRV and 3CDRV virus strains were successfully rescued in our previous study. In the present study, we found no difference in virulence between 3CRV and severe strains. However, the capacity of replication and to cause cell injury of 3CDRV strain decreased in vitro, especially at 39.5 °C. Replacement of 3CD region in the severe strain led to milder symptoms, less body weight loss, and lower viral load in ICR mice. Histopathological findings indicated less severe injury in mice infected with 3CDRV strain. This study suggests that the 3CD region contributes to the attenuation of the severe strain, including its replication capacity and temperature sensitivity.

Full Text

Duke Authors

Cited Authors

  • Li, J; Gao, F; Hao, SB; Cheng, D; Zhang, WQ; Lin, B; Zhao, L; Yu, XJ; Wang, ZY; Wen, HL

Published Date

  • October 2017

Published In

Volume / Issue

  • 30 / 10

Start / End Page

  • 767 - 771

PubMed ID

  • 29122098

International Standard Serial Number (ISSN)

  • 0895-3988

Digital Object Identifier (DOI)

  • 10.3967/bes2017.103

Language

  • eng

Conference Location

  • China