Towards living guidelines on cardiorenal outcomes in diabetes: A pilot project of the Taskforce of the Guideline Workshop 2020.

Journal Article (Review;Journal Article)

In June 2020, the Taskforce of the Guideline Workshop 2019 convened via teleconferencing to initiate a pilot project that demonstrates the various processes and considerations involved in developing high-quality, evidence-based clinical practice guidelines for the medical management of individuals with type 2 diabetes (T2D) and its associated comorbidities, including cardiovascular disease (CVD) and chronic kidney disease (CKD). The goal of the pilot project was to create evidence-based guidelines for use of sodium-glucose transport protein 2 inhibitors (SGLT2-I) when managing very high risk T2D patients, evidenced by the presence of both CVD and CKD. For this purpose the Taskforce represented a guideline panel and made use of synthesized evidence from an ongoing BMJ Rapid Recommendations project on SGLT2-I and GLP-1 receptor agonists. Results from the Taskforce pilot project demonstrated the value, feasibility and utility of using a step-wise approach to identifying and grading evidence and then developing actionable recommendations for utilizing SGLT2-I in this at-risk T2D population. This report describes the various steps involved in the process and explains how it can be utilized to rapidly develop recommendations in a format that is easy to use and can be quickly updated as new evidence becomes available, also within the emerging concept of living guidelines.

Full Text

Duke Authors

Cited Authors

  • Marx, N; Ryden, L; Brosius, F; Ceriello, A; Cheung, M; Cosentino, F; Green, J; Kellerer, M; Koob, S; Kosiborod, M; Prashant Nedungadi, T; Rodbard, HW; Vandvik, PO; Ji, L; Sheu, WH-H; Standl, E; Schnell, O

Published Date

  • July 2021

Published In

Volume / Issue

  • 177 /

Start / End Page

  • 108870 -

PubMed ID

  • 34044026

Electronic International Standard Serial Number (EISSN)

  • 1872-8227

International Standard Serial Number (ISSN)

  • 0168-8227

Digital Object Identifier (DOI)

  • 10.1016/j.diabres.2021.108870


  • eng