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Conditional specification of endomesoderm.

Publication ,  Journal Article
McClay, DR; Croce, JC; Warner, JF
Published in: Cells & development
September 2021

Early in animal development many cells are conditionally specified based on observations that those cells can be directed toward alternate fates. The endomesoderm is so named because early specification produces cells that often have been observed to simultaneously express both early endoderm and mesoderm transcription factors. Experiments with these cells demonstrate that their progeny can directed entirely toward endoderm or mesoderm, whereas normally they establish both germ layers. This review examines the mechanisms that initiate the conditional endomesoderm state, its metastability, and the mechanisms that resolve that state into definitive endoderm and mesoderm.

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Published In

Cells & development

DOI

EISSN

2667-2901

ISSN

2667-291X

Publication Date

September 2021

Volume

167

Start / End Page

203716

Related Subject Headings

  • Signal Transduction
  • Sea Urchins
  • Models, Biological
  • Mesoderm
  • Humans
  • Endoderm
  • Body Patterning
  • Animals
 

Citation

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McClay, D. R., Croce, J. C., & Warner, J. F. (2021). Conditional specification of endomesoderm. Cells & Development, 167, 203716. https://doi.org/10.1016/j.cdev.2021.203716
McClay, David R., Jenifer C. Croce, and Jacob F. Warner. “Conditional specification of endomesoderm.Cells & Development 167 (September 2021): 203716. https://doi.org/10.1016/j.cdev.2021.203716.
McClay DR, Croce JC, Warner JF. Conditional specification of endomesoderm. Cells & development. 2021 Sep;167:203716.
McClay, David R., et al. “Conditional specification of endomesoderm.Cells & Development, vol. 167, Sept. 2021, p. 203716. Epmc, doi:10.1016/j.cdev.2021.203716.
McClay DR, Croce JC, Warner JF. Conditional specification of endomesoderm. Cells & development. 2021 Sep;167:203716.

Published In

Cells & development

DOI

EISSN

2667-2901

ISSN

2667-291X

Publication Date

September 2021

Volume

167

Start / End Page

203716

Related Subject Headings

  • Signal Transduction
  • Sea Urchins
  • Models, Biological
  • Mesoderm
  • Humans
  • Endoderm
  • Body Patterning
  • Animals