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Noninvasive neuromodulation of the prefrontal cortex in mental health disorders.

Publication ,  Journal Article
Regenold, WT; Deng, Z-D; Lisanby, SH
Published in: Neuropsychopharmacology
January 2022

More than any other brain region, the prefrontal cortex (PFC) gives rise to the singularity of human experience. It is therefore frequently implicated in the most distinctly human of all disorders, those of mental health. Noninvasive neuromodulation, including electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) among others, can-unlike pharmacotherapy-directly target the PFC and its neural circuits. Direct targeting enables significantly greater on-target therapeutic effects compared with off-target adverse effects. In contrast to invasive neuromodulation approaches, such as deep-brain stimulation (DBS), noninvasive neuromodulation can reversibly modulate neural activity from outside the scalp. This combination of direct targeting and reversibility enables noninvasive neuromodulation to iteratively change activity in the PFC and its neural circuits to reveal causal mechanisms of both disease processes and healthy function. When coupled with neuronavigation and neurophysiological readouts, noninvasive neuromodulation holds promise for personalizing PFC neuromodulation to relieve symptoms of mental health disorders by optimizing the function of the PFC and its neural circuits. ClinicalTrials.gov Identifier: NCT03191058.

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Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

January 2022

Volume

47

Issue

1

Start / End Page

361 / 372

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Transcranial Direct Current Stimulation
  • Psychiatry
  • Prefrontal Cortex
  • Mental Health
  • Humans
  • Brain
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences
 

Citation

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Regenold, W. T., Deng, Z.-D., & Lisanby, S. H. (2022). Noninvasive neuromodulation of the prefrontal cortex in mental health disorders. Neuropsychopharmacology, 47(1), 361–372. https://doi.org/10.1038/s41386-021-01094-3
Regenold, William T., Zhi-De Deng, and Sarah H. Lisanby. “Noninvasive neuromodulation of the prefrontal cortex in mental health disorders.Neuropsychopharmacology 47, no. 1 (January 2022): 361–72. https://doi.org/10.1038/s41386-021-01094-3.
Regenold WT, Deng Z-D, Lisanby SH. Noninvasive neuromodulation of the prefrontal cortex in mental health disorders. Neuropsychopharmacology. 2022 Jan;47(1):361–72.
Regenold, William T., et al. “Noninvasive neuromodulation of the prefrontal cortex in mental health disorders.Neuropsychopharmacology, vol. 47, no. 1, Jan. 2022, pp. 361–72. Pubmed, doi:10.1038/s41386-021-01094-3.
Regenold WT, Deng Z-D, Lisanby SH. Noninvasive neuromodulation of the prefrontal cortex in mental health disorders. Neuropsychopharmacology. 2022 Jan;47(1):361–372.

Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

January 2022

Volume

47

Issue

1

Start / End Page

361 / 372

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Transcranial Direct Current Stimulation
  • Psychiatry
  • Prefrontal Cortex
  • Mental Health
  • Humans
  • Brain
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences