Noninvasive neuromodulation of the prefrontal cortex in mental health disorders.

Journal Article (Journal Article;Review)

More than any other brain region, the prefrontal cortex (PFC) gives rise to the singularity of human experience. It is therefore frequently implicated in the most distinctly human of all disorders, those of mental health. Noninvasive neuromodulation, including electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) among others, can-unlike pharmacotherapy-directly target the PFC and its neural circuits. Direct targeting enables significantly greater on-target therapeutic effects compared with off-target adverse effects. In contrast to invasive neuromodulation approaches, such as deep-brain stimulation (DBS), noninvasive neuromodulation can reversibly modulate neural activity from outside the scalp. This combination of direct targeting and reversibility enables noninvasive neuromodulation to iteratively change activity in the PFC and its neural circuits to reveal causal mechanisms of both disease processes and healthy function. When coupled with neuronavigation and neurophysiological readouts, noninvasive neuromodulation holds promise for personalizing PFC neuromodulation to relieve symptoms of mental health disorders by optimizing the function of the PFC and its neural circuits. Identifier: NCT03191058.

Full Text

Duke Authors

Cited Authors

  • Regenold, WT; Deng, Z-D; Lisanby, SH

Published Date

  • January 2022

Published In

Volume / Issue

  • 47 / 1

Start / End Page

  • 361 - 372

PubMed ID

  • 34272471

Pubmed Central ID

  • PMC8617166

Electronic International Standard Serial Number (EISSN)

  • 1740-634X

Digital Object Identifier (DOI)

  • 10.1038/s41386-021-01094-3


  • eng

Conference Location

  • England