The role of posterior wall isolation in catheter ablation of persistent atrial fibrillation.

Journal Article (Journal Article;Review)

The left atrial posterior wall has many embryologic, anatomic, and electrophysiologic characteristics, that are important for the initiation and maintenance of persistent atrial fibrillation. The left atrial posterior wall is a potential target for ablation in patients with persistent atrial fibrillation, a population in whom pulmonary vein isolation alone has resulted in unsatisfactory recurrence rates. Published clinical studies report conflicting results on the safety and efficacy of posterior wall isolation. Emerging technologies including optimized use of radiofrequency ablation, pulse field ablation, and combined endocardial/epicardial ablation may optimize approaches to posterior wall isolation and reduce the risk of injury to nearby structures such as the esophagus. Critical evaluation of future and ongoing clinical studies of posterior wall isolation requires careful scrutiny of many characteristics, including intraprocedural definition of posterior wall isolation, concomitant extrapulmonary vein ablation, and study endpoints.

Full Text

Duke Authors

Cited Authors

  • Clarke, J-RD; Piccini, JP; Friedman, DJ

Published Date

  • September 2021

Published In

Volume / Issue

  • 32 / 9

Start / End Page

  • 2567 - 2576

PubMed ID

  • 34258794

Electronic International Standard Serial Number (EISSN)

  • 1540-8167

Digital Object Identifier (DOI)

  • 10.1111/jce.15164


  • eng

Conference Location

  • United States