Effectiveness and acceptability of a multidisciplinary approach in improving the care of patients with advanced chronic kidney disease: a pilot study.

Journal Article (Journal Article)


This study aimed at determining the feasibility of conducting a large-scale pragmatic effectiveness study on the implementation of multidisciplinary care (MDC) program for patients with advanced chronic kidney disease (CKD).


This is a single-arm pre-post intervention design pilot study over 12 months. Participants with an estimated glomerular filtration rate (eGFR) between 11 and 20 ml/min/1.73m2 were screened and recruited at the initial MDC clinic visit and followed for 12 months. Clinical parameters, KDQOL -36, questionnaires, and interviews were collected, administered, and analysed for enrolment and completion rates, baseline characteristics, implementation fidelity, adherence to CKD interventions, eGFR decline, CKD complications, health-related quality of life, and participants' acceptability of the program.


The study enrolment and completion rates were 43.1% (50/116 screened) and 66.0% (33/50 recruited) respectively. The participants had a mean age of 68.5 years (SD9.0) and a mean eGFR of 15.4 ml/min/1.73m2 (3.2). After 12 months of MDC program, there was increased adherence to CKD interventions (difference  - 0.6(1.0), 95%CI  - 1.1,  - 0.1, p = 0.02). There was good participants' acceptability of the program with participants being more satisfied with the waiting time and having a better understanding of kidney failure after attending the program. No difference in the eGFR decline noted (difference 0.0 ml/min/1.73m2 (5.3), 95%CI  - 1.9, 1.9, p = 1.00).


Our pilot data suggest increased adherence to CKD interventions and good acceptability to MDC program, albeit no difference in eGFR decline probably because of the small sample size. However, reasons for overall low enrolment and completion rates need to be explored and addressed while designing a future large-scale randomised controlled trial.

Full Text

Duke Authors

Cited Authors

  • Kwek, JL; Griva, K; Kaur, N; Chong, KY; Chua, ZY; Sim, GHA; Ng, LC; Yong, PW; Tung, Y-T; Lim, LWW; Teo, SH; Choo, JCJ; Foo, MWY; Jafar, TH

Published Date

  • July 22, 2021

Published In

PubMed ID

  • 34292492

Electronic International Standard Serial Number (EISSN)

  • 1573-2584

International Standard Serial Number (ISSN)

  • 0301-1623

Digital Object Identifier (DOI)

  • 10.1007/s11255-021-02946-z


  • eng