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STING suppresses bone cancer pain via immune and neuronal modulation.

Publication ,  Journal Article
Wang, K; Donnelly, CR; Jiang, C; Liao, Y; Luo, X; Tao, X; Bang, S; McGinnis, A; Lee, M; Hilton, MJ; Ji, R-R
Published in: Nat Commun
July 27, 2021

Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and bone destruction, for which there is no efficacious treatment. Here, using multiple mouse models of bone cancer, we report that agonists of the immune regulator STING (stimulator of interferon genes) confer remarkable protection against cancer pain, bone destruction, and local tumor burden. Repeated systemic administration of STING agonists robustly attenuates bone cancer-induced pain and improves locomotor function. Interestingly, STING agonists produce acute pain relief through direct neuronal modulation. Additionally, STING agonists protect against local bone destruction and reduce local tumor burden through modulation of osteoclast and immune cell function in the tumor microenvironment, providing long-term cancer pain relief. Finally, these in vivo effects are dependent on host-intrinsic STING and IFN-I signaling. Overall, STING activation provides unique advantages in controlling bone cancer pain through distinct and synergistic actions on nociceptors, immune cells, and osteoclasts.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

July 27, 2021

Volume

12

Issue

1

Start / End Page

4558

Location

England

Related Subject Headings

  • Xanthones
  • Tumor Microenvironment
  • Tumor Burden
  • Signal Transduction
  • Receptor, Interferon alpha-beta
  • Osteogenesis
  • Osteoclasts
  • Nociception
  • Neurons
  • Neoplasm Metastasis
 

Citation

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Wang, K., Donnelly, C. R., Jiang, C., Liao, Y., Luo, X., Tao, X., … Ji, R.-R. (2021). STING suppresses bone cancer pain via immune and neuronal modulation. Nat Commun, 12(1), 4558. https://doi.org/10.1038/s41467-021-24867-2
Wang, Kaiyuan, Christopher R. Donnelly, Changyu Jiang, Yihan Liao, Xin Luo, Xueshu Tao, Sangsu Bang, et al. “STING suppresses bone cancer pain via immune and neuronal modulation.Nat Commun 12, no. 1 (July 27, 2021): 4558. https://doi.org/10.1038/s41467-021-24867-2.
Wang K, Donnelly CR, Jiang C, Liao Y, Luo X, Tao X, et al. STING suppresses bone cancer pain via immune and neuronal modulation. Nat Commun. 2021 Jul 27;12(1):4558.
Wang, Kaiyuan, et al. “STING suppresses bone cancer pain via immune and neuronal modulation.Nat Commun, vol. 12, no. 1, July 2021, p. 4558. Pubmed, doi:10.1038/s41467-021-24867-2.
Wang K, Donnelly CR, Jiang C, Liao Y, Luo X, Tao X, Bang S, McGinnis A, Lee M, Hilton MJ, Ji R-R. STING suppresses bone cancer pain via immune and neuronal modulation. Nat Commun. 2021 Jul 27;12(1):4558.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

July 27, 2021

Volume

12

Issue

1

Start / End Page

4558

Location

England

Related Subject Headings

  • Xanthones
  • Tumor Microenvironment
  • Tumor Burden
  • Signal Transduction
  • Receptor, Interferon alpha-beta
  • Osteogenesis
  • Osteoclasts
  • Nociception
  • Neurons
  • Neoplasm Metastasis