Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial.

Journal Article (Journal Article;Multicenter Study)

INTRODUCTION: Effective strategies to recruit older adults with mild cognitive impairment (MCI) into nonpharmacological intervention trials are lacking. METHODS: Recruitment for EXERT, a multisite randomized controlled 18-month trial examining the effects of aerobic exercise on cognitive trajectory in adults with amnestic MCI, involved a diverse portfolio of strategies to enroll 296 participants. RESULTS: Recruitment occurred September 2016 through March 2020 and was initially slow. After mass mailings of 490,323 age- and geo-targeted infographic postcards and brochures, recruitment rates increased substantially, peaking at 16 randomizations/month in early 2020. Mass mailings accounted for 52% of randomized participants, whereas 25% were recruited from memory clinic rosters, electronic health records, and national and local registries. Other sources included news broadcasts, public service announcements (PSA), local advertising, and community presentations. DISCUSSION: Age- and geo-targeted mass mailing of infographic materials was the most effective approach in recruiting older adults with amnestic MCI into an 18-month exercise trial.

Full Text

Duke Authors

Cited Authors

  • Shadyab, AH; LaCroix, AZ; Feldman, HH; van Dyck, CH; Okonkwo, OC; Tam, SP; Fairchild, JK; Welsh-Bohmer, KA; Matthews, G; Bennett, D; Shadyab, AA; Schafer, KA; Morrison, RH; Kipperman, SA; Mason, J; Tan, D; Thomas, RG; Cotman, CW; Baker, LD; ADCS EXERT Study Group,

Published Date

  • November 2021

Published In

Volume / Issue

  • 17 / 11

Start / End Page

  • 1808 - 1817

PubMed ID

  • 34297895

Pubmed Central ID

  • PMC9292825

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1002/alz.12401


  • eng

Conference Location

  • United States