Cobalt(II)-Catalyzed [4+2] Annulation of Picolinamides with Alkynes via C-H Bond Activation.

Journal Article (Journal Article)

A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl-substituted 1H-benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co-oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.

Full Text

Duke Authors

Cited Authors

  • Yao, Y; Lin, Q; Yang, W; Yang, W; Gu, F; Guo, W; Yang, D

Published Date

  • May 2020

Published In

Volume / Issue

  • 26 / 25

Start / End Page

  • 5607 - 5610

PubMed ID

  • 32045038

Electronic International Standard Serial Number (EISSN)

  • 1521-3765

International Standard Serial Number (ISSN)

  • 0947-6539

Digital Object Identifier (DOI)

  • 10.1002/chem.202000411


  • eng