Cobalt(II)-Catalyzed [4+2] Annulation of Picolinamides with Alkynes via C-H Bond Activation.

Journal Article (Journal Article)

A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl-substituted 1H-benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co-oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.

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Duke Authors

Yang, Weitao

Cited Authors

Yao, Y; Lin, Q; Yang, W; Yang, W; Gu, F; Guo, W; Yang, D

Published Date

May 2020

Published In

Chemistry (Weinheim an Der Bergstrasse, Germany)

Volume / Issue

26 / 25

Start / End Page

5607 - 5610

PubMed ID

32045038

Electronic International Standard Serial Number (EISSN)

1521-3765

International Standard Serial Number (ISSN)

0947-6539

Digital Object Identifier (DOI)

10.1002/chem.202000411

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