The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells.

Journal Article (Journal Article;Review)

Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis. During periods of metabolic stress, the subcellular location of p27Kip1 largely dictates its function. Cytoplasmic p27Kip1 has been found to be promote cellular resilience through autophagy and anti-apoptotic mechanisms. Nuclear p27Kip1, however, inhibits cell cycle progression and makes the cell susceptible to quiescence, apoptosis, and/or senescence. Cellular location of p27Kip1 is regulated, in part, by phosphorylation by various kinases, including Akt and AMPK. Aging promotes nuclear localization of p27Kip1 and a predisposition to senescence or apoptosis. Here, we will review the role of p27Kip1 in healthy and aging cells with a particular emphasis on the interplay between autophagy and apoptosis.

Full Text

Duke Authors

Cited Authors

  • McKay, LK; White, JP

Published Date

  • June 8, 2021

Published In

Volume / Issue

  • 10 / 6

PubMed ID

  • 34201101

Pubmed Central ID

  • PMC8229180

Electronic International Standard Serial Number (EISSN)

  • 2073-4409

Digital Object Identifier (DOI)

  • 10.3390/cells10061430

Language

  • eng

Conference Location

  • Switzerland