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SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

Publication ,  Journal Article
Huot, N; Rascle, P; Petitdemange, C; Contreras, V; Stürzel, CM; Baquero, E; Harper, JL; Passaes, C; Legendre, R; Varet, H; Madec, Y ...
Published in: Nat Commun
February 24, 2021

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

February 24, 2021

Volume

12

Issue

1

Start / End Page

1282

Location

England

Related Subject Headings

  • Transcriptome
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • NK Cell Lectin-Like Receptor Subfamily C
  • Male
  • Macaca
  • Lymphoid Tissue
  • Lymph Nodes
  • Killer Cells, Natural
 

Citation

APA
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ICMJE
MLA
NLM
Huot, N., Rascle, P., Petitdemange, C., Contreras, V., Stürzel, C. M., Baquero, E., … Müller-Trutwin, M. (2021). SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity. Nat Commun, 12(1), 1282. https://doi.org/10.1038/s41467-021-21402-1
Huot, Nicolas, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, et al. “SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.Nat Commun 12, no. 1 (February 24, 2021): 1282. https://doi.org/10.1038/s41467-021-21402-1.
Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, et al. SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity. Nat Commun. 2021 Feb 24;12(1):1282.
Huot, Nicolas, et al. “SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.Nat Commun, vol. 12, no. 1, Feb. 2021, p. 1282. Pubmed, doi:10.1038/s41467-021-21402-1.
Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M. SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity. Nat Commun. 2021 Feb 24;12(1):1282.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

February 24, 2021

Volume

12

Issue

1

Start / End Page

1282

Location

England

Related Subject Headings

  • Transcriptome
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • NK Cell Lectin-Like Receptor Subfamily C
  • Male
  • Macaca
  • Lymphoid Tissue
  • Lymph Nodes
  • Killer Cells, Natural