RNA modification of an RNA modifier prevents self-RNA sensing.
Journal Article (Journal Article)
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.
Full Text
Duke Authors
Cited Authors
- Snider, DL; Horner, SM
Published Date
- July 2021
Published In
Volume / Issue
- 19 / 7
Start / End Page
- e3001342 -
PubMed ID
- 34329302
Pubmed Central ID
- PMC8323910
Electronic International Standard Serial Number (EISSN)
- 1545-7885
Digital Object Identifier (DOI)
- 10.1371/journal.pbio.3001342
Language
- eng
Conference Location
- United States