RNA modification of an RNA modifier prevents self-RNA sensing.

Journal Article (Journal Article)

A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.

Full Text

Duke Authors

Cited Authors

  • Snider, DL; Horner, SM

Published Date

  • July 2021

Published In

Volume / Issue

  • 19 / 7

Start / End Page

  • e3001342 -

PubMed ID

  • 34329302

Pubmed Central ID

  • PMC8323910

Electronic International Standard Serial Number (EISSN)

  • 1545-7885

Digital Object Identifier (DOI)

  • 10.1371/journal.pbio.3001342


  • eng

Conference Location

  • United States