RNA modification of an RNA modifier prevents self-RNA sensing.
Publication
, Journal Article
Snider, DL; Horner, SM
Published in: PLoS Biol
July 2021
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.
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Published In
PLoS Biol
DOI
EISSN
1545-7885
Publication Date
July 2021
Volume
19
Issue
7
Start / End Page
e3001342
Location
United States
Related Subject Headings
- RNA-Binding Proteins
- RNA, Double-Stranded
- Interferons
- Developmental Biology
- Adenosine Deaminase
- Adenosine
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 30 Agricultural, veterinary and food sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Snider, D. L., & Horner, S. M. (2021). RNA modification of an RNA modifier prevents self-RNA sensing. PLoS Biol, 19(7), e3001342. https://doi.org/10.1371/journal.pbio.3001342
Snider, Daltry L., and Stacy M. Horner. “RNA modification of an RNA modifier prevents self-RNA sensing.” PLoS Biol 19, no. 7 (July 2021): e3001342. https://doi.org/10.1371/journal.pbio.3001342.
Snider DL, Horner SM. RNA modification of an RNA modifier prevents self-RNA sensing. PLoS Biol. 2021 Jul;19(7):e3001342.
Snider, Daltry L., and Stacy M. Horner. “RNA modification of an RNA modifier prevents self-RNA sensing.” PLoS Biol, vol. 19, no. 7, July 2021, p. e3001342. Pubmed, doi:10.1371/journal.pbio.3001342.
Snider DL, Horner SM. RNA modification of an RNA modifier prevents self-RNA sensing. PLoS Biol. 2021 Jul;19(7):e3001342.
Published In
PLoS Biol
DOI
EISSN
1545-7885
Publication Date
July 2021
Volume
19
Issue
7
Start / End Page
e3001342
Location
United States
Related Subject Headings
- RNA-Binding Proteins
- RNA, Double-Stranded
- Interferons
- Developmental Biology
- Adenosine Deaminase
- Adenosine
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 30 Agricultural, veterinary and food sciences
- 11 Medical and Health Sciences