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PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer.

Publication ,  Journal Article
Koshkin, VS; Patel, VG; Ali, A; Bilen, MA; Ravindranathan, D; Park, JJ; Kellezi, O; Cieslik, M; Shaya, J; Cabal, A; Brown, L; Labriola, M ...
Published in: Prostate Cancer Prostatic Dis
September 2022

PURPOSE: Prostate cancer is a heterogeneous disease with variable clinical outcomes. Despite numerous recent approvals of novel therapies, castration-resistant prostate cancer remains lethal. A "real-world" clinical-genomic database is urgently needed to enhance our characterization of advanced prostate cancer and further enable precision oncology. METHODS: The Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort (PROMISE) is a consortium whose aims are to establish a repository of de-identified clinical and genomic patient data that are linked to patient outcomes. The consortium structure includes a (1) bio-informatics committee to standardize genomic data and provide quality control, (2) biostatistics committee to independently perform statistical analyses, (3) executive committee to review and select proposals of relevant questions for the consortium to address, (4) diversity/inclusion committee to address important clinical questions pertaining to racial disparities, and (5) patient advocacy committee to understand patient perspectives to improve patients' quality of care. RESULTS: The PROMISE consortium was formed by 16 academic institutions in early 2020 and a secure RedCap database was created. The first patient record was entered into the database in April 2020 and over 1000 records have been entered as of early 2021. Data entry is proceeding as planned with the goal to have over 2500 patient records by the end of 2021. CONCLUSIONS: The PROMISE consortium provides a powerful clinical-genomic platform to interrogate and address data gaps that have arisen with increased genomic testing in the clinical management of prostate cancer. The dataset incorporates data from patient populations that are often underrepresented in clinical trials, generates new hypotheses to direct further research, and addresses important clinical questions that are otherwise difficult to investigate in prospective studies.

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Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2022

Volume

25

Issue

3

Start / End Page

388 / 396

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prospective Studies
  • Precision Medicine
  • Medical Oncology
  • Male
  • Humans
  • Genomics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

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Koshkin, V. S., Patel, V. G., Ali, A., Bilen, M. A., Ravindranathan, D., Park, J. J., … McKay, R. (2022). PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis, 25(3), 388–396. https://doi.org/10.1038/s41391-021-00433-1
Koshkin, Vadim S., Vaibhav G. Patel, Alicia Ali, Mehmet A. Bilen, Deepak Ravindranathan, Joseph J. Park, Olesia Kellezi, et al. “PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer.Prostate Cancer Prostatic Dis 25, no. 3 (September 2022): 388–96. https://doi.org/10.1038/s41391-021-00433-1.
Koshkin VS, Patel VG, Ali A, Bilen MA, Ravindranathan D, Park JJ, et al. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):388–96.
Koshkin, Vadim S., et al. “PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer.Prostate Cancer Prostatic Dis, vol. 25, no. 3, Sept. 2022, pp. 388–96. Pubmed, doi:10.1038/s41391-021-00433-1.
Koshkin VS, Patel VG, Ali A, Bilen MA, Ravindranathan D, Park JJ, Kellezi O, Cieslik M, Shaya J, Cabal A, Brown L, Labriola M, Graham LS, Pritchard C, Tripathi A, Nusrat S, Barata P, Jang A, Chen SR, Garje R, Acharya L, Hwang C, Pilling A, Oh W, Jun T, Natesan D, Nguyen C, Kilari D, Pierro M, Thapa B, Cackowski F, Mack A, Heath E, Marshall CH, Tagawa ST, Halabi S, Schweizer MT, Armstrong A, Dorff T, Alva A, McKay R. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):388–396.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2022

Volume

25

Issue

3

Start / End Page

388 / 396

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prospective Studies
  • Precision Medicine
  • Medical Oncology
  • Male
  • Humans
  • Genomics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences