Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report.

Journal Article

There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF-related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team-based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.

Full Text

Duke Authors

Cited Authors

  • Benjamin, EJ; Al-Khatib, SM; Desvigne-Nickens, P; Alonso, A; Djoussé, L; Forman, DE; Gillis, AM; Hendriks, JML; Hills, MT; Kirchhof, P; Link, MS; Marcus, GM; Mehra, R; Murray, KT; Parkash, R; Piña, IL; Redline, S; Rienstra, M; Sanders, P; Somers, VK; Van Wagoner, DR; Wang, PJ; Cooper, LS; Go, AS

Published Date

  • August 17, 2021

Published In

Volume / Issue

  • 10 / 16

Start / End Page

  • e021566 -

PubMed ID

  • 34351783

Pubmed Central ID

  • PMC8475065

Electronic International Standard Serial Number (EISSN)

  • 2047-9980

Digital Object Identifier (DOI)

  • 10.1161/JAHA.121.021566


  • eng

Conference Location

  • England