A Connectome-Wide Functional Signature of Trait Anger

Journal Article (Journal Article)

Past research on the brain correlates of trait anger has been limited by small sample sizes, a focus on relatively few regions of interest, and poor test–retest reliability of functional brain measures. To address these limitations, we conducted a data-driven analysis of variability in connectome-wide functional connectivity in a sample of 1,048 young adult volunteers. Multidimensional matrix regression analysis showed that self-reported trait anger maps onto variability in the whole-brain functional connectivity patterns of three brain regions that serve action-related functions: bilateral supplementary motor areas and the right lateral frontal pole. We then demonstrate that trait anger modulates the functional connectivity of these regions with canonical brain networks supporting somatomotor, affective, self-referential, and visual information processes. Our findings offer novel neuroimaging evidence for interpreting trait anger as a greater propensity to provoked action, which supports ongoing efforts to understand its utility as a potential transdiagnostic marker for disordered states characterized by aggressive behavior.

Full Text

Duke Authors

Cited Authors

  • Kim, MJ; Elliott, ML; Knodt, AR; Hariri, AR

Published Date

  • January 1, 2021

Published In

Electronic International Standard Serial Number (EISSN)

  • 2167-7034

International Standard Serial Number (ISSN)

  • 2167-7026

Digital Object Identifier (DOI)

  • 10.1177/21677026211030240

Citation Source

  • Scopus