The Long Neglected Cycloidal Mass Analyzer.

Journal Article (Journal Article)

In 1938, Walker Bleakney and John A. Hipple first described the cycloidal mass analyzer as the only mass analyzer configuration capable of "perfect" ion focusing. Why has their geometry been largely neglected for many years and how might it earn a respectable place in the world of modern chemical analysis? This Perspective explores the properties of the cycloidal mass analyzer and identifies the lack of suitable ion array detectors as a significant reason why cycloidal mass analyzers are not widely used. The recent development of capacitive transimpedance amplifier array detectors can enable several techniques using cycloidal mass analyzers including spatially coded apertures and single particle mass analysis with a "virtual-slit", helping the cycloidal mass analyzer earn a respectable place in chemical analysis.

Full Text

Duke Authors

Cited Authors

  • Piacentino, EL; Serpa, RB; Horvath, KL; Vyas, R; Aloui, T; Parker, CB; Carlson, JB; Keogh, J; Sperline, RP; Sartorelli, ML; Stoner, BR; Gehm, ME; Glass, JT; Denton, MB; Amsden, JJ

Published Date

  • August 2021

Published In

Volume / Issue

  • 93 / 33

Start / End Page

  • 11357 - 11363

PubMed ID

  • 34370439

Electronic International Standard Serial Number (EISSN)

  • 1520-6882

International Standard Serial Number (ISSN)

  • 0003-2700

Digital Object Identifier (DOI)

  • 10.1021/acs.analchem.1c02001


  • eng