Role of Alternative Splicing in Regulating Host Response to Viral Infection.

Journal Article (Journal Article;Review)

The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and important layer of regulation to fine-tune host immune responses. Here, we review the functional significance of alternative splicing in innate immune responses to viral infection. We describe how several central components of the Type I and III interferon pathways encode spliced isoforms to regulate IFN activation and function. Additionally, the functional roles of splicing factors and modulators in antiviral immunity are discussed. Lastly, we discuss how cell death pathways are regulated by alternative splicing as well as the potential role of this regulation on host immunity and viral infection. Altogether, these studies highlight the importance of RNA splicing in regulating host-virus interactions and suggest a role in downregulating antiviral innate immunity; this may be critical to prevent pathological inflammation.

Full Text

Duke Authors

Cited Authors

  • Liao, K-C; Garcia-Blanco, MA

Published Date

  • July 8, 2021

Published In

Volume / Issue

  • 10 / 7

PubMed ID

  • 34359890

Pubmed Central ID

  • PMC8306335

Electronic International Standard Serial Number (EISSN)

  • 2073-4409

Digital Object Identifier (DOI)

  • 10.3390/cells10071720


  • eng

Conference Location

  • Switzerland