Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.

Journal Article (Journal Article;Review)

Epidural spinal cord compression (ESCC) secondary to spine metastases is one of the most devastating sequelae of primary cancer as it may lead to muscle weakness, paresthesia, pain, and paralysis. Spine metastases occur through a multistep process that can result in eventual ESCC; however, the lack of a preclinical model to effectively recapitulate each step of this metastatic cascade and the symptom burden of ESCC has limited our understanding of this disease process. In this review, we discuss animal models that best recapitulate ESCC. We start with a broad discussion of commonly used models of bone metastasis and end with a focused discussion of models used to specifically study ESCC. Orthotopic models offer the most authentic recapitulation of metastasis development; however, they rarely result in symptomatic ESCC and are challenging to replicate. Conversely, models that involve injection of tumor cells directly into the bloodstream or bone better mimic the symptoms of ESCC; however, they provide limited insight into the epithelial to mesenchymal transition and natural hematogenous spread of tumor cells. Therefore, until an ideal model is created, it is critical to select an animal model that is specifically designed to answer the scientific question of interest.

Full Text

Duke Authors

Cited Authors

  • Price, MJ; Baëta, C; Dalton, TE; Nguyen, A; Lavau, C; Pennington, Z; Sciubba, DM; Goodwin, CR

Published Date

  • November 2021

Published In

Volume / Issue

  • 155 /

Start / End Page

  • 122 - 134

PubMed ID

  • 34343682

Electronic International Standard Serial Number (EISSN)

  • 1878-8769

Digital Object Identifier (DOI)

  • 10.1016/j.wneu.2021.07.121

Language

  • eng

Conference Location

  • United States