Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.

Journal Article (Journal Article)

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.

Full Text

Duke Authors

Cited Authors

  • Scheetz, MH; Pais, GM; Lodise, TP; Tong, SYC; Davis, JS; O'Donnell, JN; Liu, J; Neely, M; Prozialeck, WC; Lamar, PC; Rhodes, NJ; Holland, T; Avedissian, SN

Published Date

  • September 17, 2021

Published In

Volume / Issue

  • 65 / 10

Start / End Page

  • e0106021 -

PubMed ID

  • 34339278

Pubmed Central ID

  • PMC8448150

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.01060-21


  • eng

Conference Location

  • United States