Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study.

Journal Article (Journal Article)

While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the "PRONE" Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as defined by respiratory rate ≥ 20/min or an oxyhemoglobin saturation (SpO2) ≤ 93% without supplemental oxygen [1]. The PRONE trial was designed to investigate the effects of prone positioning on need for escalation in respiratory support, as defined by need for transition to a higher acuity level of care, increased fraction of inspired oxygen (FiO2), or the initiation of invasive mechanical ventilation. Secondary objectives were to assess the duration of effect of prone positioning on respiratory parameters such as respiratory rate and SpO2, as well as other outcomes such as time to discharge or transition in level of care.

Full Text

Duke Authors

Cited Authors

  • Friedman, E; Franzone, J; Ko, ER; Corey, K; Mock, J; Alavian, N; Schwartz, A; Drummond, MB; Suber, T; Linstrum, K; Bain, W; Castiblanco, SA; Zak, M; Zaeh, S; Gupta, I; Damarla, M; Punjabi, NM

Published Date

  • October 2021

Published In

Volume / Issue

  • 109 /

Start / End Page

  • 106541 -

PubMed ID

  • 34400361

Pubmed Central ID

  • PMC8363159

Electronic International Standard Serial Number (EISSN)

  • 1559-2030

Digital Object Identifier (DOI)

  • 10.1016/j.cct.2021.106541


  • eng

Conference Location

  • United States