The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.

Journal Article (Journal Article)

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.

Full Text

Duke Authors

Cited Authors

  • Stefaniak, E; Płonka, D; Drew, SC; Bossak-Ahmad, K; Haas, KL; Pushie, MJ; Faller, P; Wezynfeld, NE; Bal, W

Published Date

  • December 2018

Published In

Volume / Issue

  • 10 / 12

Start / End Page

  • 1723 - 1727

PubMed ID

  • 30489586

Electronic International Standard Serial Number (EISSN)

  • 1756-591X

International Standard Serial Number (ISSN)

  • 1756-5901

Digital Object Identifier (DOI)

  • 10.1039/c8mt00274f

Language

  • eng