The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.
Publication
, Journal Article
Stefaniak, E; Płonka, D; Drew, SC; Bossak-Ahmad, K; Haas, KL; Pushie, MJ; Faller, P; Wezynfeld, NE; Bal, W
Published in: Metallomics : integrated biometal science
December 2018
Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.
Duke Scholars
Published In
Metallomics : integrated biometal science
DOI
EISSN
1756-591X
ISSN
1756-5901
Publication Date
December 2018
Volume
10
Issue
12
Start / End Page
1723 / 1727
Related Subject Headings
- Serum Albumin, Human
- Protein Binding
- Peptide Fragments
- Models, Molecular
- Humans
- Copper Transporter 1
- Copper
- Cation Transport Proteins
- Biological Transport
- Binding Sites
Citation
APA
Chicago
ICMJE
MLA
NLM
Stefaniak, E., Płonka, D., Drew, S. C., Bossak-Ahmad, K., Haas, K. L., Pushie, M. J., … Bal, W. (2018). The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : Integrated Biometal Science, 10(12), 1723–1727. https://doi.org/10.1039/c8mt00274f
Stefaniak, Ewelina, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M Jake Pushie, Peter Faller, Nina E. Wezynfeld, and Wojciech Bal. “The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.” Metallomics : Integrated Biometal Science 10, no. 12 (December 2018): 1723–27. https://doi.org/10.1039/c8mt00274f.
Stefaniak E, Płonka D, Drew SC, Bossak-Ahmad K, Haas KL, Pushie MJ, et al. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : integrated biometal science. 2018 Dec;10(12):1723–7.
Stefaniak, Ewelina, et al. “The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.” Metallomics : Integrated Biometal Science, vol. 10, no. 12, Dec. 2018, pp. 1723–27. Epmc, doi:10.1039/c8mt00274f.
Stefaniak E, Płonka D, Drew SC, Bossak-Ahmad K, Haas KL, Pushie MJ, Faller P, Wezynfeld NE, Bal W. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. Metallomics : integrated biometal science. 2018 Dec;10(12):1723–1727.
Published In
Metallomics : integrated biometal science
DOI
EISSN
1756-591X
ISSN
1756-5901
Publication Date
December 2018
Volume
10
Issue
12
Start / End Page
1723 / 1727
Related Subject Headings
- Serum Albumin, Human
- Protein Binding
- Peptide Fragments
- Models, Molecular
- Humans
- Copper Transporter 1
- Copper
- Cation Transport Proteins
- Biological Transport
- Binding Sites