The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.
Journal Article (Journal Article)
Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.
Full Text
Duke Authors
Cited Authors
- Stefaniak, E; Płonka, D; Drew, SC; Bossak-Ahmad, K; Haas, KL; Pushie, MJ; Faller, P; Wezynfeld, NE; Bal, W
Published Date
- December 2018
Published In
Volume / Issue
- 10 / 12
Start / End Page
- 1723 - 1727
PubMed ID
- 30489586
Electronic International Standard Serial Number (EISSN)
- 1756-591X
International Standard Serial Number (ISSN)
- 1756-5901
Digital Object Identifier (DOI)
- 10.1039/c8mt00274f
Language
- eng