Relugolix, an oral gonadotropin-releasing hormone antagonist for the treatment of prostate cancer.

Journal Article (Journal Article)

Androgen deprivation therapy using gonadotropin-releasing hormone (GnRH) analogues is standard treatment for intermediate and advanced prostate cancer. GnRH agonist therapy results in an initial testosterone flare, and increased metabolic and cardiovascular risks. The GnRH antagonist relugolix is able to reduce serum testosterone levels in men with prostate cancer without inducing testosterone flare. In the HERO Phase III trial, relugolix was superior to leuprolide acetate at rapidly reducing testosterone and continuously suppressing testosterone, with faster post-treatment recovery of testosterone levels. Relugolix was associated with a 54% lower incidence of major adverse cardiovascular events than leuprolide acetate. As the first oral GnRH antagonist approved for the treatment of advanced prostate cancer, relugolix offers a new treatment option.

Full Text

Duke Authors

Cited Authors

  • George, DJ; Dearnaley, DP

Published Date

  • November 2021

Published In

Volume / Issue

  • 17 / 33

Start / End Page

  • 4431 - 4446

PubMed ID

  • 34409852

Electronic International Standard Serial Number (EISSN)

  • 1744-8301

Digital Object Identifier (DOI)

  • 10.2217/fon-2021-0575


  • eng

Conference Location

  • England