MTORC1-dependent crinophagy regulates glucagon content in pancreatic α-cells.

Journal Article (Journal Article)

Hormone synthesis and secretion is a highly regulated process governed by metabolic cues. Although peptide hormone action is largely governed by the rate of its synthesis and secretion by endocrine cells, and the levels of its receptors on the target cells, intracellular degradation of the hormone-containing secretory vesicles by lysosomes (crinophagy) adds an additional layer of regulation. In our recent study, we uncovered the regulatory mechanism governing the crinophagic turnover of GCG (glucagon), a glycoprotein hormone secreted by pancreatic α-cells. Our results showed that inhibition of MTORC1 induces crinophagy-mediated degradation of glucagon and decreases its secretion in response to hypoglycemia. Furthermore, we demonstrated that crinophagy-regulated glucagon turnover does not involve macroautophagy. These results suggest that modulation of crinophagy may serve as a novel therapeutic strategy to regulate hormone secretion in endocrine and metabolic pathologies.

Full Text

Duke Authors

Cited Authors

  • Rajak, S; Yen, PM; Sinha, RA

Published Date

  • October 2021

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • 3269 - 3270

PubMed ID

  • 34382918

Pubmed Central ID

  • PMC8526004

Electronic International Standard Serial Number (EISSN)

  • 1554-8635

Digital Object Identifier (DOI)

  • 10.1080/15548627.2021.1961074

Language

  • eng

Conference Location

  • United States