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Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study.

Publication ,  Journal Article
Harte, SE; Wiseman, J; Wang, Y; Smith, AR; Yang, CC; Helmuth, M; Kreder, K; Kruger, GH; Gillespie, BW; Amundsen, C; Kirkali, Z; Lai, HH ...
Published in: J Urol
January 2022

PURPOSE: The objective of this study was to investigate the presence of nonbladder sensory abnormalities in participants with overactive bladder syndrome (OAB). MATERIALS AND METHODS: Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) study participants with OAB symptoms and controls were recruited from 6 U.S. tertiary referral centers. Quantitative sensory testing (QST) was performed to determine pressure pain sensitivity at the thumbnail bed and auditory sensitivity. Fixed and mixed effect multivariable linear regressions and Weibull models were used to compare QST responses between groups. Pearson correlations were used to assess the relationship between QST measures. Associations between QST and self-reported symptoms were explored with linear regression. RESULTS: A total of 297 participants were analyzed (191 OAB, 106 controls; 76% white, 51% male). OAB cases were older than controls (57.4 vs 52.2 years, p=0.015). No significant differences in experimental thumbnail (nonbladder) pain or auditory sensitivity were detected between OAB cases and controls. Correlations between pressure and auditory derived metrics were weak to moderate overall for both groups, with some significantly stronger correlations for cases. Exploratory analyses indicated increased pressure pain and auditory sensitivity were modestly associated with greater self-reported bladder pain and pain interference with physical function. CONCLUSIONS: As a group, no significant differences between OAB cases and controls were observed in experimental nonbladder pain or auditory sensitivity during QST. Associations between QST outcomes and clinical pain raise the possibility of centrally mediated sensory amplification in some individuals with OAB.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

January 2022

Volume

207

Issue

1

Start / End Page

161 / 171

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urinary Bladder, Overactive
  • Pain Measurement
  • Pain
  • Middle Aged
  • Male
  • Humans
  • Hearing Disorders
  • Female
  • Cohort Studies
 

Citation

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Harte, S. E., Wiseman, J., Wang, Y., Smith, A. R., Yang, C. C., Helmuth, M., … LURN Study Group, . (2022). Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study. J Urol, 207(1), 161–171. https://doi.org/10.1097/JU.0000000000002147
Harte, Steven E., Jon Wiseman, Ying Wang, Abigail R. Smith, Claire C. Yang, Margaret Helmuth, Karl Kreder, et al. “Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study.J Urol 207, no. 1 (January 2022): 161–71. https://doi.org/10.1097/JU.0000000000002147.
Harte, Steven E., et al. “Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study.J Urol, vol. 207, no. 1, Jan. 2022, pp. 161–71. Pubmed, doi:10.1097/JU.0000000000002147.
Harte SE, Wiseman J, Wang Y, Smith AR, Yang CC, Helmuth M, Kreder K, Kruger GH, Gillespie BW, Amundsen C, Kirkali Z, Lai HH, LURN Study Group. Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study. J Urol. 2022 Jan;207(1):161–171.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

January 2022

Volume

207

Issue

1

Start / End Page

161 / 171

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urinary Bladder, Overactive
  • Pain Measurement
  • Pain
  • Middle Aged
  • Male
  • Humans
  • Hearing Disorders
  • Female
  • Cohort Studies