LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.
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, Journal Article
Zhang, M; Otsuki, K; Kikuchi, T; Bai, Z-S; Zhou, D; Huang, L; Chen, C-H; Morris-Natschke, SL; Lee, K-H; Li, N; Koike, K; Li, W
Published in: J Nat Prod
August 27, 2021
Structurally diverse tigliane diterpenoids have drawn significant research interest for drug discovery over many decades. Using LC-MS-guided fractionation and separation, the first phytochemical investigation on Wikstroemia lamatsoensis led to the isolation of eight tiglianes (1-8), including two new compounds, wikstrocin D (1) and wikstrocin E (2). The new structures were elucidated based on extensive physicochemical and spectroscopic analyses. The characteristic ESIMS/MS fragmentations of tiglianes 1-8 were also summarized. Among the isolated tiglianes, three compounds (8, 5, and 7) showed the most potent anti-HIV activity, with IC50 values of 0.18, 3.8, and 12.8 nM, respectively.
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Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
August 27, 2021
Volume
84
Issue
8
Start / End Page
2366 / 2373
Location
United States
Related Subject Headings
- Wikstroemia
- Phytochemicals
- Phorbols
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- HIV-1
- Diterpenes
- China
- Cell Line
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, M., Otsuki, K., Kikuchi, T., Bai, Z.-S., Zhou, D., Huang, L., … Li, W. (2021). LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis. J Nat Prod, 84(8), 2366–2373. https://doi.org/10.1021/acs.jnatprod.1c00570
Zhang, Mi, Kouharu Otsuki, Takashi Kikuchi, Zi-Song Bai, Di Zhou, Li Huang, Chin-Ho Chen, et al. “LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.” J Nat Prod 84, no. 8 (August 27, 2021): 2366–73. https://doi.org/10.1021/acs.jnatprod.1c00570.
Zhang M, Otsuki K, Kikuchi T, Bai Z-S, Zhou D, Huang L, et al. LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis. J Nat Prod. 2021 Aug 27;84(8):2366–73.
Zhang, Mi, et al. “LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.” J Nat Prod, vol. 84, no. 8, Aug. 2021, pp. 2366–73. Pubmed, doi:10.1021/acs.jnatprod.1c00570.
Zhang M, Otsuki K, Kikuchi T, Bai Z-S, Zhou D, Huang L, Chen C-H, Morris-Natschke SL, Lee K-H, Li N, Koike K, Li W. LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis. J Nat Prod. 2021 Aug 27;84(8):2366–2373.
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
August 27, 2021
Volume
84
Issue
8
Start / End Page
2366 / 2373
Location
United States
Related Subject Headings
- Wikstroemia
- Phytochemicals
- Phorbols
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- HIV-1
- Diterpenes
- China
- Cell Line