Type 2 Diabetes Mellitus: A Pathophysiologic Perspective.

Journal Article (Journal Article)

Type 2 Diabetes Mellitus (T2DM) is characterized by chronically elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia). When the blood glucose concentration is 100 milligrams/deciliter the bloodstream of an average adult contains about 5-10 grams of glucose. Carbohydrate-restricted diets have been used effectively to treat obesity and T2DM for over 100 years, and their effectiveness may simply be due to lowering the dietary contribution to glucose and insulin levels, which then leads to improvements in hyperglycemia and hyperinsulinemia. Treatments for T2DM that lead to improvements in glycemic control and reductions in blood insulin levels are sensible based on this pathophysiologic perspective. In this article, a pathophysiological argument for using carbohydrate restriction to treat T2DM will be made.

Full Text

Duke Authors

Cited Authors

  • Westman, EC

Published Date

  • 2021

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 707371 -

PubMed ID

  • 34447776

Pubmed Central ID

  • PMC8384107

International Standard Serial Number (ISSN)

  • 2296-861X

Digital Object Identifier (DOI)

  • 10.3389/fnut.2021.707371


  • eng

Conference Location

  • Switzerland