Inherited Variation in Gene Expression

Journal Article

Variation in gene expression constitutes an important source of biological variability within and between populations that is likely to contribute significantly to phenotypic diversity. Recent conceptual, technical, and methodological advances have enabled the genome-scale dissection of transcriptional variation. Here, we outline common approaches for detecting gene expression quantitative trait loci, and summarize the insights gleaned from these studies regarding the genetic architecture of transcriptional variation and the nature of regulatory alleles. Particular emphasis is placed on human studies, and we discuss experimental designs that ensure that increasingly large and complex studies continue to advance our understanding of gene expression variation. We conclude by discussing the evolution of gene expression levels, and we explore prospects for leveraging new technological developments to investigate inherited variation in gene expression in even greater depth.

Full Text

Duke Authors

Cited Authors

  • Skelly, DA; Ronald, J; Akey, JM

Published Date

  • September 1, 2009

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 313 - 332

Published By

Electronic International Standard Serial Number (EISSN)

  • 1545-293X

International Standard Serial Number (ISSN)

  • 1527-8204

Digital Object Identifier (DOI)

  • 10.1146/annurev-genom-082908-150121

Language

  • en