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Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.

Publication ,  Journal Article
Xiong, F; Ma, W; Bénazéraf, B; Mahadevan, L; Pourquié, O
Published in: Developmental cell
November 2020

Tissues undergoing morphogenesis impose mechanical effects on one another. How developmental programs adapt to or take advantage of these effects remains poorly explored. Here, using a combination of live imaging, modeling, and microsurgical perturbations, we show that the axial and paraxial tissues in the forming avian embryonic body coordinate their rates of elongation through mechanical interactions. First, a cell motility gradient drives paraxial presomitic mesoderm (PSM) expansion, resulting in compression of the axial neural tube and notochord; second, elongation of axial tissues driven by PSM compression and polarized cell intercalation pushes the caudal progenitor domain posteriorly; finally, the axial push drives the lateral movement of midline PSM cells to maintain PSM growth and cell motility. These interactions form an engine-like positive feedback loop, which sustains a shared elongation rate for coupled tissues. Our results demonstrate a key role of inter-tissue forces in coordinating distinct body axis tissues during their co-elongation.

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Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2020

Volume

55

Issue

3

Start / End Page

354 / 366.e5

Related Subject Headings

  • Quail
  • Organogenesis
  • Mesoderm
  • Embryo, Nonmammalian
  • Developmental Biology
  • Computer Simulation
  • Chick Embryo
  • Cell Tracking
  • Cell Polarity
  • Cell Movement
 

Citation

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ICMJE
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Xiong, F., Ma, W., Bénazéraf, B., Mahadevan, L., & Pourquié, O. (2020). Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos. Developmental Cell, 55(3), 354-366.e5. https://doi.org/10.1016/j.devcel.2020.08.007
Xiong, Fengzhu, Wenzhe Ma, Bertrand Bénazéraf, L. Mahadevan, and Olivier Pourquié. “Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.Developmental Cell 55, no. 3 (November 2020): 354-366.e5. https://doi.org/10.1016/j.devcel.2020.08.007.
Xiong F, Ma W, Bénazéraf B, Mahadevan L, Pourquié O. Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos. Developmental cell. 2020 Nov;55(3):354-366.e5.
Xiong, Fengzhu, et al. “Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.Developmental Cell, vol. 55, no. 3, Nov. 2020, pp. 354-366.e5. Epmc, doi:10.1016/j.devcel.2020.08.007.
Xiong F, Ma W, Bénazéraf B, Mahadevan L, Pourquié O. Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos. Developmental cell. 2020 Nov;55(3):354-366.e5.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2020

Volume

55

Issue

3

Start / End Page

354 / 366.e5

Related Subject Headings

  • Quail
  • Organogenesis
  • Mesoderm
  • Embryo, Nonmammalian
  • Developmental Biology
  • Computer Simulation
  • Chick Embryo
  • Cell Tracking
  • Cell Polarity
  • Cell Movement