Therapy With 177Lu-DOTATATE: Clinical Implementation and Impact on Care of Patients With Neuroendocrine Tumors.

Journal Article (Journal Article;Review)

OBJECTIVE. The purpose of this article is to enhance knowledge of the clinical implementation of peptide receptor radionuclide therapy (PRRT) and its impact on care of patients with neuroendocrine tumors. CONCLUSION. Most well differentiated and some moderately and poorly differentiated neuroendocrine tumors express large numbers of somatostatin receptors on their cell surfaces. PRRT targets these cells with 177Lu-DOTATATE, which is a medium-energy beta emitter. Since this agent received U.S. Food and Drug Administration approval in 2018, tremendous effort has been exerted at institutions throughout the United States toward proper implementation of this promising therapy. This review summarizes clinical implementation of PRRT and its impact on patient care.

Full Text

Duke Authors

Cited Authors

  • Kendi, AT; Halfdanarson, TR; Packard, A; Dundar, A; Subramaniam, RM

Published Date

  • August 2019

Published In

Volume / Issue

  • 213 / 2

Start / End Page

  • 309 - 317

PubMed ID

  • 31039017

Electronic International Standard Serial Number (EISSN)

  • 1546-3141

Digital Object Identifier (DOI)

  • 10.2214/AJR.19.21123


  • eng

Conference Location

  • United States