ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer.

Journal Article (Journal Article)

The American College of Radiology (ACR) and American College of Nuclear Medicine (ACNM) collaborated to develop a clinical practice document for the performance of fluciclovine positron-emission tomography (PET) / computed tomography (CT) in the evaluation of patients with suspected prostate cancer recurrence based on the elevation of prostate-specific antigen (PSA) level (biochemical recurrence) after prior therapy. Prostate cancer is the third leading cause of cancer death in the United States. Up to 50% of patients diagnosed with prostate cancer will develop biochemical failure after initial therapy. The differentiation of local from extraprostatic recurrence plays a critical role in patient management. The use of functional imaging targeting features of cancer metabolism has proven highly useful in this regard. Amino acid transport is upregulated in prostate cancer. Fluciclovine (anti-1-amino-3-F-18-fluorocyclobutane-1-carboxylic acid, FACBC, Axumin™) is an artificial amino acid PET tracer which demonstrates utility in the diagnosis of recurrent prostate cancer with significant added value to conventional imaging.

Full Text

Duke Authors

Cited Authors

  • Savir-Baruch, B; Banks, KP; McConathy, JE; Molchanova-Cook, OP; Parent, EE; Takalkar, A; Tulchinsky, M; Yu, JQ; Subramaniam, RM; Schuster, DM

Published Date

  • December 2018

Published In

Volume / Issue

  • 43 / 12

Start / End Page

  • 909 - 917

PubMed ID

  • 30325827

Electronic International Standard Serial Number (EISSN)

  • 1536-0229

Digital Object Identifier (DOI)

  • 10.1097/RLU.0000000000002310


  • eng

Conference Location

  • United States