Precision Medicine and PET-Computed Tomography in Pediatric Malignancies.

Journal Article (Journal Article;Review)

Fluorine-18 fluorodeoxyglucose (18F-FDG) PET-computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose 18F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT-based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (131I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.

Full Text

Duke Authors

Cited Authors

  • Sanli, Y; Yilmaz, E; Subramaniam, RM

Published Date

  • October 2017

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 423 - 435

PubMed ID

  • 28867113

Electronic International Standard Serial Number (EISSN)

  • 1879-9809

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2017.05.009


  • eng

Conference Location

  • United States