PET/Computed Tomography and Precision Medicine: Musculoskeletal Sarcoma.

Journal Article (Journal Article;Review)

Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome. 18F-FDG PET/computed tomography (CT) is indicated in staging of patients with high-grade sarcomas and acts as a surrogate marker of histopathologic grade, guiding biopsy to most aggressive portion of the tumor. Pretherapy and posttherapy 18F-FDG PET/CT metabolic parameters are reliable indicators of survival in patients with sarcoma with an important role in posttreatment response assessment, enabling the treatment plan to be modified in nonresponders. 18F-FDG PET/CT is particularly useful in the evaluation of molecular targeted therapies, which induce metabolic change before structural change.

Full Text

Duke Authors

Cited Authors

  • Kandathil, A; Subramaniam, RM

Published Date

  • October 2017

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 475 - 488

PubMed ID

  • 28867117

Electronic International Standard Serial Number (EISSN)

  • 1879-9809

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2017.05.005


  • eng

Conference Location

  • United States