Molecular Imaging and Precision Medicine in Head and Neck Cancer.

Journal Article (Journal Article;Review)

The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.

Full Text

Duke Authors

Cited Authors

  • Mena, E; Thippsandra, S; Yanamadala, A; Redy, S; Pattanayak, P; Subramaniam, RM

Published Date

  • January 2017

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 7 - 25

PubMed ID

  • 27863568

Electronic International Standard Serial Number (EISSN)

  • 1879-9809

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2016.08.009

Language

  • eng

Conference Location

  • United States