The Current and Evolving Role of PET in Personalized Management of Lung Cancer.

Journal Article (Journal Article;Review)

Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non-small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.

Full Text

Duke Authors

Cited Authors

  • Mena, E; Yanamadala, A; Cheng, G; Subramaniam, RM

Published Date

  • July 2016

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 243 - 259

PubMed ID

  • 27321029

Electronic International Standard Serial Number (EISSN)

  • 1879-9809

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2016.02.010


  • eng

Conference Location

  • United States