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FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy.

Publication ,  Journal Article
Taghipour, M; Sheikhbahaei, S; Wray, R; Agrawal, N; Richmon, J; Kang, H; Subramaniam, RM
Published in: AJR Am J Roentgenol
May 2016

OBJECTIVE: The purpose of this study was to assess the value of posttreatment FDG PET/CT in patients with squamous cell carcinoma of the head and neck (HNSCC) treated with primary surgical resection with or without adjuvant concurrent chemoradiotherapy. MATERIALS AND METHODS: A total of 98 HNSCC patients were treated with primary surgical resection and had undergone PET/CT within 6 months of treatment completion. The accuracy of the scans and the added value to clinical assessment and impact on management were established based on the clinical information before and after each scan. Overall survival of patients was estimated with Kaplan-Meier curves. RESULTS: Of the total 98 scans, 25 (25.5%) were interpreted as positive and 73 (74.5%) as negative. The sensitivity of posttreatment PET/CT was 80.0%; specificity, 89.5%; positive predictive value, 66.7%; negative predictive value, 94.4%; and accuracy, 87.5%. These scans were helpful in excluding tumor in 31.8% of patients with clinical suspicion of residual disease and identifying suspected residual disease in 13.2% of patients with no prior clinical suspicion. Multivariate regression analysis showed that tumor size, grade (p = 0.041), scan type (p = 0.002), and scan result (p = 0.005) were independent covariates associated with overall survival. Kaplan-Meier analysis showed a significant difference and association in overall survival between patients with a positive versus a negative posttherapy PET/CT scan result (hazard ratio, 5.65; 95% CI, 2.48-12.83; log rank Mantel-Cox p < 0.001). CONCLUSION: Posttreatment FDG PET/CT results had a high negative predictive value, added value to clinical assessment of 35% of patients, influenced subsequent management, and were associated with survival outcome of HNSCC patients treated with primary surgical resection.

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Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

May 2016

Volume

206

Issue

5

Start / End Page

1093 / 1100

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Squamous Cell Carcinoma of Head and Neck
  • Retrospective Studies
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Humans
 

Citation

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Taghipour, M., Sheikhbahaei, S., Wray, R., Agrawal, N., Richmon, J., Kang, H., & Subramaniam, R. M. (2016). FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy. AJR Am J Roentgenol, 206(5), 1093–1100. https://doi.org/10.2214/AJR.15.15604
Taghipour, Mehdi, Sara Sheikhbahaei, Rick Wray, Nishant Agrawal, Jeremy Richmon, Hyunseok Kang, and Rathan M. Subramaniam. “FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy.AJR Am J Roentgenol 206, no. 5 (May 2016): 1093–1100. https://doi.org/10.2214/AJR.15.15604.
Taghipour M, Sheikhbahaei S, Wray R, Agrawal N, Richmon J, Kang H, et al. FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy. AJR Am J Roentgenol. 2016 May;206(5):1093–100.
Taghipour, Mehdi, et al. “FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy.AJR Am J Roentgenol, vol. 206, no. 5, May 2016, pp. 1093–100. Pubmed, doi:10.2214/AJR.15.15604.
Taghipour M, Sheikhbahaei S, Wray R, Agrawal N, Richmon J, Kang H, Subramaniam RM. FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy. AJR Am J Roentgenol. 2016 May;206(5):1093–1100.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

May 2016

Volume

206

Issue

5

Start / End Page

1093 / 1100

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Squamous Cell Carcinoma of Head and Neck
  • Retrospective Studies
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Humans