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Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time.

Publication ,  Journal Article
Chirindel, A; Alluri, KC; Tahari, AK; Chaudhry, M; Wahl, RL; Lodge, MA; Subramaniam, RM
Published in: Clin Nucl Med
January 2015

OBJECTIVE: The objective of this study is to establish the magnitude change and interreader reliability of the liver standardized uptake value corrected for lean body mass (SULmean) in dual-time-point imaging at 1 and 2 hours and 1 and 4 hours. PATIENTS AND METHODS: Early and delayed FDG PET/CT scans were included for 28 patients (13 men and 15 women) who had normal liver by CT or ultrasound. The average uptake time between the early and delayed scans were 55 minutes (range, 44-69 minutes) for pancreatic adenocarcinoma patients (n = 19) and 184 minutes (range, 140-197 minutes) for neurofibromatosis patients (n = 9). A 30-mm-diameter spherical volume of interest was placed within the right lobe of the liver above, below, and at the level of the main portal vein by 2 independent readers. Correlation coefficients, analysis of variance, intraclass correlation coefficient, and Bland-Altman analysis were performed. RESULTS: The mean liver SULmean was between 1.39 and 1.42 and between 1.28 and 1.3 in early and delayed images, respectively (P = 0.001). There is time-dependent reduction in the mean liver SULmean at 2-hour (7%-8%) and 4-hour uptake time (15%-21%) compared with 1-hour uptake time. The correlation coefficient between delayed uptake time and liver SULmean reduction is 0.39 to 0.41 at the upper aspect of the liver. The intraclass correlation coefficient for 2 readers varied between 0.997 and 0.998 and between 0.995 and 0.999 in early and delayed images, respectively (P = 0.001). CONCLUSIONS: There is time-dependent reduction of mean liver SULmean, about 7% to 8% within the clinically relevant FDG uptake time, in the same patient with excellent interreader agreement in early and delayed images within the right lobe of the liver. Therefore, liver SULmean could represent a useful reference parameter in quantitative analysis of dual-phase FDG PET/CT in malignancy or atypical infection/inflammatory disease. Furthermore, it may be suitable as a normalization factor in currently available formulae quantifying therapy response on PET imaging.

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Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

January 2015

Volume

40

Issue

1

Start / End Page

e17 / e22

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Pancreatic Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver
 

Citation

APA
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ICMJE
MLA
NLM
Chirindel, A., Alluri, K. C., Tahari, A. K., Chaudhry, M., Wahl, R. L., Lodge, M. A., & Subramaniam, R. M. (2015). Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time. Clin Nucl Med, 40(1), e17–e22. https://doi.org/10.1097/RLU.0000000000000446
Chirindel, Alin, Krishna C. Alluri, Abdel K. Tahari, Muhammad Chaudhry, Richard L. Wahl, Martin A. Lodge, and Rathan M. Subramaniam. “Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time.Clin Nucl Med 40, no. 1 (January 2015): e17–22. https://doi.org/10.1097/RLU.0000000000000446.
Chirindel A, Alluri KC, Tahari AK, Chaudhry M, Wahl RL, Lodge MA, et al. Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time. Clin Nucl Med. 2015 Jan;40(1):e17–22.
Chirindel, Alin, et al. “Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time.Clin Nucl Med, vol. 40, no. 1, Jan. 2015, pp. e17–22. Pubmed, doi:10.1097/RLU.0000000000000446.
Chirindel A, Alluri KC, Tahari AK, Chaudhry M, Wahl RL, Lodge MA, Subramaniam RM. Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time. Clin Nucl Med. 2015 Jan;40(1):e17–e22.

Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

January 2015

Volume

40

Issue

1

Start / End Page

e17 / e22

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Pancreatic Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver