Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging.

Journal Article (Journal Article)

Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome characterized by the development of multiple peripheral nerve sheath tumors, the majority of which are benign neurofibromas. However, malignant peripheral nerve sheath tumors (MPNSTs) occur with a 10 % lifetime risk in patients with NF1, often developing within a neurofibroma. When clinical suspicion for an MPNST arises, imaging with FDG PET and MRI is performed to characterize a peripheral tumor for potential malignancy. In this report, we describe a patient with NF-1 who had two peripheral tumors with similar features by PET, both suspicious for MPNST, but differing features by MRI, one of which was subsequently determined to be an MPNST and the second to be a schwannoma.

Full Text

Duke Authors

Cited Authors

  • Ahlawat, S; Blakeley, J; Montgomery, E; Subramaniam, RM; Belzberg, A; Fayad, LM

Published Date

  • September 2013

Published In

Volume / Issue

  • 42 / 9

Start / End Page

  • 1317 - 1322

PubMed ID

  • 23649401

Pubmed Central ID

  • PMC3991125

Electronic International Standard Serial Number (EISSN)

  • 1432-2161

Digital Object Identifier (DOI)

  • 10.1007/s00256-013-1626-3


  • eng

Conference Location

  • Germany