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Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland.

Publication ,  Journal Article
Karantanis, D; Bogsrud, TV; Wiseman, GA; Mullan, BP; Subramaniam, RM; Nathan, MA; Peller, PJ; Bahn, RS; Lowe, VJ
Published in: J Nucl Med
June 2007

UNLABELLED: Our purpose was to determine the clinical significance of diffusely increased (18)F-FDG uptake in the thyroid gland as an incidental finding on PET/CT. METHODS: All patients who were found to have diffuse thyroid uptake on (18)F-FDG PET/CT in our institution between November 2004 and June 2006 were investigated and compared with an age- and sex-matched control group. The (18)F-FDG uptake in the thyroid was semiquantified using maximum standardized uptake value and correlated to the available serum thyroid-stimulating hormone (TSH) and thyroid peroxidase (TPO) antibody levels using regression analysis. RESULTS: Of the 4,732 patients, 138 (2.9%) had diffuse thyroid uptake. Clinical information was available for 133 of the 138 patients. Sixty-three (47.4%) had a prior diagnosis of hypothyroidism or autoimmune thyroiditis, of whom 56 were receiving thyroxine therapy. In the control group, consisting of 133 patients with no thyroid uptake, there were 13 (9.8%) with a prior diagnosis of hypothyroidism, 11 of whom were receiving thyroxine therapy. In the study group, 38 (28.6%) of 133 patients did not undergo any further investigation for thyroid disease, whereas 32 (24.1%) of 133 patients were examined for thyroid disease after PET. Nineteen were found with autoimmune thyroiditis or hypothyroidism, and replacement therapy was initiated in 12. No significant correlation was found between maximum standardized uptake value and TSH (P = 0.09) or TPO antibody (P = 0.68) levels. CONCLUSION: The incidental finding of increased (18)F-FDG uptake in the thyroid gland is associated with chronic lymphocytic (Hashimoto's) thyroiditis and does not seem to be affected by thyroid hormone therapy. SUV correlated neither with the degree of hypothyroidism nor with the titer of TPO antibodies.

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Published In

J Nucl Med

DOI

ISSN

0161-5505

Publication Date

June 2007

Volume

48

Issue

6

Start / End Page

896 / 901

Location

United States

Related Subject Headings

  • Thyrotropin
  • Thyroid Gland
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Iodide Peroxidase
  • Hypothyroidism
  • Humans
 

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Karantanis, D., Bogsrud, T. V., Wiseman, G. A., Mullan, B. P., Subramaniam, R. M., Nathan, M. A., … Lowe, V. J. (2007). Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland. J Nucl Med, 48(6), 896–901. https://doi.org/10.2967/jnumed.106.039024
Karantanis, Dimitrios, Trond V. Bogsrud, Gregory A. Wiseman, Brian P. Mullan, Rathan M. Subramaniam, Mark A. Nathan, Patrick J. Peller, Rebecca S. Bahn, and Val J. Lowe. “Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland.J Nucl Med 48, no. 6 (June 2007): 896–901. https://doi.org/10.2967/jnumed.106.039024.
Karantanis D, Bogsrud TV, Wiseman GA, Mullan BP, Subramaniam RM, Nathan MA, et al. Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland. J Nucl Med. 2007 Jun;48(6):896–901.
Karantanis, Dimitrios, et al. “Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland.J Nucl Med, vol. 48, no. 6, June 2007, pp. 896–901. Pubmed, doi:10.2967/jnumed.106.039024.
Karantanis D, Bogsrud TV, Wiseman GA, Mullan BP, Subramaniam RM, Nathan MA, Peller PJ, Bahn RS, Lowe VJ. Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland. J Nucl Med. 2007 Jun;48(6):896–901.

Published In

J Nucl Med

DOI

ISSN

0161-5505

Publication Date

June 2007

Volume

48

Issue

6

Start / End Page

896 / 901

Location

United States

Related Subject Headings

  • Thyrotropin
  • Thyroid Gland
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Iodide Peroxidase
  • Hypothyroidism
  • Humans