Focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of CT abnormality in PET/CT.

Journal Article (Journal Article)

OBJECTIVE: To demonstrate 3 cases of artifactual focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of any computed tomographic (CT) abnormality. MATERIALS AND METHODS: Three patients were examined: a 30-year-old man who had a positron emission tomography (PET)/computed tomography for restaging a biopsy-proven recurrence of head and neck cancer, a 68-year-old woman who was referred for initial staging of esophageal carcinoma, and a 57-year-old man who had a PET/computed tomography for initial staging of melanoma. In each case, there was intense focal activity in the lung parenchyma with no corresponding CT abnormality. Each patient was further evaluated with a repeat PET scan in days 1 and 3 in the first 2 cases and with a delayed repeat acquisition in the third case. Patients were followed for 24, 10, and 1 month, respectively. RESULTS: In the first 2 cases, the abnormal focal activity in the lungs had resolved in the repeat study. In the third case, the focus of increased activity in the lung had moved more peripherally in the delayed acquisition. Clinical follow-up was negative for disease in the corresponding pulmonary parenchymal sites. CONCLUSIONS: The finding of significant focal accumulation of fluoro-deoxy-glucose in the lung parenchyma in the absence of corresponding CT abnormality was artifactual. This was likely due to injection technique and the creation of particulate embolus. Positron emission tomography/Computed tomographic readers should be aware of this type of artifact to avoid misinterpretation.

Full Text

Duke Authors

Cited Authors

  • Karantanis, D; Subramaniam, RM; Mullan, BP; Peller, PJ; Wiseman, GA

Published Date

  • September 2007

Published In

Volume / Issue

  • 31 / 5

Start / End Page

  • 800 - 805

PubMed ID

  • 17895795

International Standard Serial Number (ISSN)

  • 0363-8715

Digital Object Identifier (DOI)

  • 10.1097/RCT.0b013e3180340376

Language

  • eng

Conference Location

  • United States