Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.

Journal Article (Journal Article)

On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.

Full Text

Duke Authors

Cited Authors

  • Watts, R; Steinklein, JM; Waldman, L; Zhou, X; Filippi, CG

Published Date

  • April 2019

Published In

Volume / Issue

  • 40 / 4

Start / End Page

  • 648 - 651

PubMed ID

  • 30679221

Pubmed Central ID

  • PMC7048502

Electronic International Standard Serial Number (EISSN)

  • 1936-959X

Digital Object Identifier (DOI)

  • 10.3174/ajnr.A5931


  • eng

Conference Location

  • United States