Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.
Publication
, Journal Article
Watts, R; Steinklein, JM; Waldman, L; Zhou, X; Filippi, CG
Published in: AJNR Am J Neuroradiol
April 2019
On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.
Duke Scholars
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Published In
AJNR Am J Neuroradiol
DOI
EISSN
1936-959X
Publication Date
April 2019
Volume
40
Issue
4
Start / End Page
648 / 651
Location
United States
Related Subject Headings
- Organometallic Compounds
- Nuclear Medicine & Medical Imaging
- Neuroimaging
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Injections, Spinal
- Image Processing, Computer-Assisted
- Humans
- Glymphatic System
Citation
APA
Chicago
ICMJE
MLA
NLM
Watts, R., Steinklein, J. M., Waldman, L., Zhou, X., & Filippi, C. G. (2019). Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI. AJNR Am J Neuroradiol, 40(4), 648–651. https://doi.org/10.3174/ajnr.A5931
Watts, R., J. M. Steinklein, L. Waldman, X. Zhou, and C. G. Filippi. “Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.” AJNR Am J Neuroradiol 40, no. 4 (April 2019): 648–51. https://doi.org/10.3174/ajnr.A5931.
Watts R, Steinklein JM, Waldman L, Zhou X, Filippi CG. Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI. AJNR Am J Neuroradiol. 2019 Apr;40(4):648–51.
Watts, R., et al. “Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.” AJNR Am J Neuroradiol, vol. 40, no. 4, Apr. 2019, pp. 648–51. Pubmed, doi:10.3174/ajnr.A5931.
Watts R, Steinklein JM, Waldman L, Zhou X, Filippi CG. Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI. AJNR Am J Neuroradiol. 2019 Apr;40(4):648–651.
Published In
AJNR Am J Neuroradiol
DOI
EISSN
1936-959X
Publication Date
April 2019
Volume
40
Issue
4
Start / End Page
648 / 651
Location
United States
Related Subject Headings
- Organometallic Compounds
- Nuclear Medicine & Medical Imaging
- Neuroimaging
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Injections, Spinal
- Image Processing, Computer-Assisted
- Humans
- Glymphatic System