Congenital Tuberculosis: A New Concern in the Neonatal Intensive Care Unit.

Journal Article (Review;Journal Article)

Background

Congenital tuberculosis (TB) is rare in the United States. Recent immigration patterns to the United States have made the diagnosis of congenital TB an important public health issue.

Purpose

To explore the epidemiology, pathophysiology, diagnostic evaluation, treatment, and prognosis for congenital TB. The implications for exposed healthcare professionals in the neonatal intensive care unit (NICU) setting are also explored.

Methods/search strategy

Relevant articles were accessed via PubMed, CINAHL, and Google Scholar.

Findings/results

Until 1994, fewer than 400 cases of confirmed congenital TB had been reported in the literature worldwide. An additional 18 cases were reported from 2001 to 2005. Neonatal providers need to be aware of the potential for congenital TB infection as the immigrant population in the United States continues to increase, many of whom originate from TB endemic countries.

Implications for practice

The interpretation of TB-specific tests is problematic in newborns due to decreased sensitivity and specificity. Congenital TB should be ruled out in infants with signs and symptoms of sepsis or pneumonia and in whom broad-spectrum antibiotic therapy does not improve their clinical status.

Implications for research

The interpretation of TB-specific tests is problematic in newborns due to decreased sensitivity and specificity; more research is needed regarding best practice in diagnosis. Established protocols are needed to address the healthcare of TB-exposed providers in the NICU.

Full Text

Duke Authors

Cited Authors

  • Newberry, DM; Robertson Bell, T

Published Date

  • October 2018

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 341 - 349

PubMed ID

  • 30096058

Electronic International Standard Serial Number (EISSN)

  • 1536-0911

International Standard Serial Number (ISSN)

  • 1536-0903

Digital Object Identifier (DOI)

  • 10.1097/anc.0000000000000555

Language

  • eng