Twin-to-Twin Transfusion Syndrome: A Case Report.

Journal Article (Review;Journal Article)

PURPOSE:To present a case of twin-to-twin transfusion syndrome (TTTS), followed by discussion of the etiology, pathophysiology, prenatal diagnosis, management, complications, prognosis, and family considerations. METHODS:A literature review was conducted using MEDLINE, PubMed, CINAHL, ProQuest, and Google Scholar. The search resulted in 593 articles; 25 relevant articles were chosen. RESULTS:Approximately 1 of every 250 cases of monochorionic twins acquire TTTS. The progression of TTTS is unpredictable; nontreatment and early onset have been associated with >90 percent mortality of both twins. Neurodevelopmental impairment, preterm birth, renal hypoperfusion, growth restriction, cardiomyopathy, and hydrops fetalis have been associated with TTTS. LIMITATIONS:A paucity of research and case reports exists, limiting recommendations for optimal diagnosis, management, and treatment regimens. IMPLICATIONS FOR PRACTICE:TTTS is unpredictable in progression; earlier identification of chorionicity, diagnosis of TTTS, and improvement of treatment and management have the potential to improve the mortality and morbidity outcomes associated with TTTS.

Full Text

Duke Authors

Cited Authors

  • Bautista, TN; Krebs, TL; Jnah, A; Newberry, D

Published Date

  • September 2018

Published In

Volume / Issue

  • 37 / 5

Start / End Page

  • 292 - 302

PubMed ID

  • 30567811

Electronic International Standard Serial Number (EISSN)

  • 1539-2880

International Standard Serial Number (ISSN)

  • 0730-0832

Digital Object Identifier (DOI)

  • 10.1891/0730-0832.37.5.292


  • eng