Neonatal Rhizomelic Chondrodysplasia Punctata Type 1: Weaving Evidence Into Clinical Practice.

Journal Article (Review;Journal Article)

Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic peroxisome biogenesis disorder with a reported incidence of 1 in 100 000 live births. The 3 genetic subtypes of RCDP are acquired by an autosomal recessive inheritance pattern. RCDP type 1 accounts for greater than 90% of all aggregate cases. Differentiating between the 3 subtypes of RCDP, as well as disorders characterized by similar punctate cartilaginous changes, is essential to guide an appropriate postnatal plan of care. Management strategies are focused toward associated clinical manifestations and require an interdisciplinary approach including ophthalmology, cardiovascular, endocrine, physical and occupational therapy, and neurology. Purposeful and frequent collaboration among all members of the neonatal/pediatric interdisciplinary team is necessary to optimize outcomes for the neonate and the family unit. The purpose of this article is to anticipate the needs of both patients with known and prenatal diagnosis of RCDP type 1 and patients with suspected clinical diagnosis of RCDP type 1 in the immediate neonatal period and to guide the appropriate plan of care. This article presents a case report of type I RCDP, as well as describes genetic influences, symptoms, diagnosis, management, and prognosis.

Full Text

Duke Authors

Cited Authors

  • Landino, J; Jnah, AJ; Newberry, DM; Iben, SC

Published Date

  • October 2017

Published In

Volume / Issue

  • 31 / 4

Start / End Page

  • 350 - 357

PubMed ID

  • 29068853

Electronic International Standard Serial Number (EISSN)

  • 1550-5073

International Standard Serial Number (ISSN)

  • 0893-2190

Digital Object Identifier (DOI)

  • 10.1097/jpn.0000000000000282

Language

  • eng