Congenital Mesoblastic Nephroma Presenting With Refractory Hypertension in a Premature Neonate: A Case Study.

Journal Article (Journal Article)

The most common nonencapsulated solid renal tumor in the neonatal period is congenital mesoblastic nephroma. Mesoblastic nephroma is a solid lesion originating within or extending from the renal parenchyma. These tumors proliferate rapidly, typically within 3-6 months after birth. Mesoblastic nephromas are stratified by classification as either classical (benign) or atypical (malignant); masses composed of both benign and malignant cells are also reported. The hallmark clinical manifestation of mesoblastic nephroma is a palpable abdominal mass, which may be accompanied by hypertension, hypercalcemia, hematuria, and polyuria. Differentiating between benign and malignant renal tumors is essential to invoke a timely, evidence-based management and treatment plan. With appropriate surgical intervention in a timely manner, prognosis is excellent and mesoblastic nephroma is considered curable. We present a case involving a premature infant with congenital mesoblastic nephroma with discussion of embryology, pathophysiology, diagnostic, management, and prognostic implications for the neonate and family.

Full Text

Duke Authors

Cited Authors

  • Robertson-Bell, T; Newberry, DM; Jnah, AJ; DeMeo, SD

Published Date

  • January 2017

Published In

Volume / Issue

  • 36 / 1

Start / End Page

  • 32 - 39

PubMed ID

  • 28137351

Electronic International Standard Serial Number (EISSN)

  • 1539-2880

International Standard Serial Number (ISSN)

  • 0730-0832

Digital Object Identifier (DOI)

  • 10.1891/0730-0832.36.1.32


  • eng