Control of Human Viral Infections by Natural Killer Cells

Journal Article

Natural killer (NK) cells are effector cells of the innate immune system and are important in the control of viral infections. Their relevance is reflected by the multiple mechanisms evolved by viruses to evade NK cell–mediated immune responses. Over recent years, our understanding of the interplay between NK cell immunity and viral pathogenesis has improved significantly. Here, we review the role of NK cells in the control of four important viral infections in humans: cytomegalovirus, influenza virus, HIV-1, and hepatitis C virus.

Full Text

Duke Authors

Cited Authors

  • Jost, S; Altfeld, M

Published Date

  • March 21, 2013

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 163 - 194

Published By

Electronic International Standard Serial Number (EISSN)

  • 1545-3278

International Standard Serial Number (ISSN)

  • 0732-0582

Digital Object Identifier (DOI)

  • 10.1146/annurev-immunol-032712-100001


  • en