Skip to main content
Journal cover image

Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.

Publication ,  Journal Article
Li, Y; Jiang, H; Jin, X; Wang, H; Ji, JS; Yan, LL
Published in: Brain and behavior
October 2021

The oldest-old (aged ≥80 years) are the fastest growing population segment and age is related to cognitive impairment. We aimed to estimate the association between cognitive impairment and all-cause mortality, in addition to the relationship with different cognitive subdomains among the oldest-old in China.We analyzed 25,285 participants recruited from 22 out of 30 provinces in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 1998 to 2008, with mortality follow-up until 2014. Cognitive function was measured by the Chinese-version 30-item Mini-Mental State Examination (MMSE), classified as no (MMSE score: 25-30), mild (18-24), moderate (10-17), and severe (0-9) impairment. We used time-dependent Cox model to evaluate the relationship between time-varying cognition and mortality.The relationship between cognition and mortality showed a dose-response pattern among the overall population. Compared to those with no impairment, participants with moderate (HR = 1.41, 95% CI 1.28-1.56) and severe (HR = 1.77, 95% CI 1.59-1.96) cognitive impairment showed increased mortality risk. Impairment in the subdomain of orientation was independently associated with increased mortality risk (HR = 1.20, 95% CI 1.05-1.36) among participants without overall cognitive impairment. Urban and rural residents had similar mortality risk.A consistent dose-response pattern existed between cognitive impairment and all-cause mortality. Orientation was associated with mortality in the population without cognitive impairment. Similar mortality regardless of residence areas indicated scarce health care and treatment for cognitive impairment in China from 1998 to 2014.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Brain and behavior

DOI

EISSN

2162-3279

ISSN

2162-3279

Publication Date

October 2021

Volume

11

Issue

10

Start / End Page

e2325

Related Subject Headings

  • Prospective Studies
  • Mental Status and Dementia Tests
  • Longitudinal Studies
  • Humans
  • Cognitive Dysfunction
  • Cognition
  • China
  • Aged, 80 and over
  • Adult
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, Y., Jiang, H., Jin, X., Wang, H., Ji, J. S., & Yan, L. L. (2021). Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older. Brain and Behavior, 11(10), e2325. https://doi.org/10.1002/brb3.2325
Li, Yaxi, Heng Jiang, Xurui Jin, Huali Wang, John S. Ji, and Lijing L. Yan. “Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.Brain and Behavior 11, no. 10 (October 2021): e2325. https://doi.org/10.1002/brb3.2325.
Li Y, Jiang H, Jin X, Wang H, Ji JS, Yan LL. Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older. Brain and behavior. 2021 Oct;11(10):e2325.
Li, Yaxi, et al. “Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.Brain and Behavior, vol. 11, no. 10, Oct. 2021, p. e2325. Epmc, doi:10.1002/brb3.2325.
Li Y, Jiang H, Jin X, Wang H, Ji JS, Yan LL. Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older. Brain and behavior. 2021 Oct;11(10):e2325.
Journal cover image

Published In

Brain and behavior

DOI

EISSN

2162-3279

ISSN

2162-3279

Publication Date

October 2021

Volume

11

Issue

10

Start / End Page

e2325

Related Subject Headings

  • Prospective Studies
  • Mental Status and Dementia Tests
  • Longitudinal Studies
  • Humans
  • Cognitive Dysfunction
  • Cognition
  • China
  • Aged, 80 and over
  • Adult
  • 5202 Biological psychology