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Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.

Publication ,  Journal Article
Pandey, A; Shah, SJ; Butler, J; Kellogg, DL; Lewis, GD; Forman, DE; Mentz, RJ; Borlaug, BA; Simon, MA; Chirinos, JA; Fielding, RA; Volpi, E ...
Published in: J Am Coll Cardiol
September 14, 2021

Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the rationale for a transdisciplinary, "gero-centric" approach to advance our understanding of EI in HFpEF and identify promising new therapeutic targets. We also provide a framework for prioritizing future research, including developing a uniform, comprehensive approach to phenotypic characterization of HFpEF, elucidating key geroscience targets for treatment, and conducting proof-of-concept trials to modify these targets.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 14, 2021

Volume

78

Issue

11

Start / End Page

1166 / 1187

Location

United States

Related Subject Headings

  • Humans
  • Heart Failure, Diastolic
  • Exercise Tolerance
  • Cardiovascular System & Hematology
  • Animals
  • Aging
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., … Kitzman, D. (2021). Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol, 78(11), 1166–1187. https://doi.org/10.1016/j.jacc.2021.07.014
Pandey, Ambarish, Sanjiv J. Shah, Javed Butler, Dean L. Kellogg, Gregory D. Lewis, Daniel E. Forman, Robert J. Mentz, et al. “Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.J Am Coll Cardiol 78, no. 11 (September 14, 2021): 1166–87. https://doi.org/10.1016/j.jacc.2021.07.014.
Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, et al. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Sep 14;78(11):1166–87.
Pandey, Ambarish, et al. “Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.J Am Coll Cardiol, vol. 78, no. 11, Sept. 2021, pp. 1166–87. Pubmed, doi:10.1016/j.jacc.2021.07.014.
Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Sep 14;78(11):1166–1187.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 14, 2021

Volume

78

Issue

11

Start / End Page

1166 / 1187

Location

United States

Related Subject Headings

  • Humans
  • Heart Failure, Diastolic
  • Exercise Tolerance
  • Cardiovascular System & Hematology
  • Animals
  • Aging
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology