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Dietary-Induced Ketogenesis: Adults Are Not Children.

Publication ,  Journal Article
Porper, K; Zach, L; Shpatz, Y; Ben-Zeev, B; Tzadok, M; Jan, E; Talianski, A; Champ, CE; Symon, Z; Anikster, Y; Lawrence, YR
Published in: Nutrients
September 2, 2021

UNLABELLED: There is increasing interest in the use of a ketogenic diet for various adult disorders; however, the ability of adults to generate ketones is unknown. Our goal was to challenge the hypothesis that there would be no difference between adults and children regarding their ability to enter ketosis. METHODS: Two populations were studied, both treated with identical very low-carbohydrate high-fat diets: a retrospective series of children with epilepsy or/and metabolic disorders (2009-2016) and a prospective clinical trial of adults with glioblastoma. Dietary intake was assessed based upon written food diaries and 24-h dietary recall. Ketogenic ratio was calculated according to [grams of fat consumed]/[grams of carbohydrate and protein consumed]. Ketone levels (β-hydroxybutyrate) were measured in blood and/or urine. RESULTS: A total of 168 encounters amongst 28 individuals were analyzed. Amongst both children and adults, ketone levels correlated with nutritional ketogenic ratio; however, the absolute ketone levels in adults were approximately one quarter of those seen in children. This difference was highly significant in a multivariate linear regression model, p < 0.0001. CONCLUSIONS: For diets with comparable ketogenic ratios, adults have lower blood ketone levels than children; consequently, high levels of nutritional ketosis are unobtainable in adults.

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Published In

Nutrients

DOI

EISSN

2072-6643

Publication Date

September 2, 2021

Volume

13

Issue

9

Location

Switzerland

Related Subject Headings

  • Retrospective Studies
  • Prospective Studies
  • Middle Aged
  • Metabolic Diseases
  • Male
  • Ketosis
  • Ketones
  • Infant
  • Humans
  • Glioma
 

Citation

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Porper, K., Zach, L., Shpatz, Y., Ben-Zeev, B., Tzadok, M., Jan, E., … Lawrence, Y. R. (2021). Dietary-Induced Ketogenesis: Adults Are Not Children. Nutrients, 13(9). https://doi.org/10.3390/nu13093093
Porper, Keren, Leor Zach, Yael Shpatz, Bruria Ben-Zeev, Michal Tzadok, Elisheva Jan, Alisa Talianski, et al. “Dietary-Induced Ketogenesis: Adults Are Not Children.Nutrients 13, no. 9 (September 2, 2021). https://doi.org/10.3390/nu13093093.
Porper K, Zach L, Shpatz Y, Ben-Zeev B, Tzadok M, Jan E, et al. Dietary-Induced Ketogenesis: Adults Are Not Children. Nutrients. 2021 Sep 2;13(9).
Porper, Keren, et al. “Dietary-Induced Ketogenesis: Adults Are Not Children.Nutrients, vol. 13, no. 9, Sept. 2021. Pubmed, doi:10.3390/nu13093093.
Porper K, Zach L, Shpatz Y, Ben-Zeev B, Tzadok M, Jan E, Talianski A, Champ CE, Symon Z, Anikster Y, Lawrence YR. Dietary-Induced Ketogenesis: Adults Are Not Children. Nutrients. 2021 Sep 2;13(9).

Published In

Nutrients

DOI

EISSN

2072-6643

Publication Date

September 2, 2021

Volume

13

Issue

9

Location

Switzerland

Related Subject Headings

  • Retrospective Studies
  • Prospective Studies
  • Middle Aged
  • Metabolic Diseases
  • Male
  • Ketosis
  • Ketones
  • Infant
  • Humans
  • Glioma