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Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus

Publication ,  Conference
Labriola, M; Slaboch, C; Ovaert, TC; Wang, T; Csaba, G; Bayer, IS; Dervishi, E; Biris, AS; Ghosh, A; Gupta, R; Biswas, A
Published in: Materials Research Society Symposium Proceedings
December 1, 2012

We show a novel, bioengineered, moldable platform for bone regeneration composed of porous bionanocomposite scaffolds made of components that are normally found in bone tissue (calcium, collagen, carbonate, sodium, and phosphorous). To accommodate high- or low-stress environments, the hardness and modulus (stiffness) of these scaffolds can be tuned in a wide range in Megapascal (MPa) to Gigapascal (GPa) regions, while maintaining the required viscoelasticity. Our approach to control the mechanical properties is based on a new formulation of mineralized bioscaffolds by incorporation of calcium carbonate in which, calcium and phosphorous are in the form of calcite, calcium polyphosphate (CPP) and hydroxyapatite (HAP). The variation in the calcium carbonate concentration allows tuning of calcite/CPP contents in the bioscaffold to tailor the degree of mineralization and mechanical and viscoelastic properties that closely match those of natural bone. Our results demonstrate an ¡framework for new bone scaffold designs for advanced bone substitute applications. © 2012 Materials Research Society.

Duke Scholars

Published In

Materials Research Society Symposium Proceedings

DOI

ISSN

0272-9172

ISBN

9781627482585

Publication Date

December 1, 2012

Volume

1465

Start / End Page

56 / 61
 

Citation

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Labriola, M., Slaboch, C., Ovaert, T. C., Wang, T., Csaba, G., Bayer, I. S., … Biswas, A. (2012). Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus. In Materials Research Society Symposium Proceedings (Vol. 1465, pp. 56–61). https://doi.org/10.1557/opl.2012.1130
Labriola, M., C. Slaboch, T. C. Ovaert, T. Wang, G. Csaba, I. S. Bayer, E. Dervishi, et al. “Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus.” In Materials Research Society Symposium Proceedings, 1465:56–61, 2012. https://doi.org/10.1557/opl.2012.1130.
Labriola M, Slaboch C, Ovaert TC, Wang T, Csaba G, Bayer IS, et al. Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus. In: Materials Research Society Symposium Proceedings. 2012. p. 56–61.
Labriola, M., et al. “Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus.” Materials Research Society Symposium Proceedings, vol. 1465, 2012, pp. 56–61. Scopus, doi:10.1557/opl.2012.1130.
Labriola M, Slaboch C, Ovaert TC, Wang T, Csaba G, Bayer IS, Dervishi E, Biris AS, Ghosh A, Gupta R, Biswas A. Engineered bone-inspired multicomponent bionanocomposite scaffolds with tunable hardness and modulus. Materials Research Society Symposium Proceedings. 2012. p. 56–61.

Published In

Materials Research Society Symposium Proceedings

DOI

ISSN

0272-9172

ISBN

9781627482585

Publication Date

December 1, 2012

Volume

1465

Start / End Page

56 / 61